New approaches towards treatment of insomnia

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چکیده

Sleep cycle Brain activity can be recorded by EEG during wakefulness and sleep (Fig 1). Light sleep referring to stages 1 and 2 shows a relatively low voltage with mixed frequency activity, while deep sleep referring to stages 3 and 4, which is also called slow-wave sleep, is characterized by increasing high voltage activity. In REM sleep brain activity resembles that of wakefulness. Healthy individuals may cycle between stages of NREM and REM throughout the night (1, 2). The average length of the first NREM-REM sleep cycle is 70-100 min with 75-80% in NREM, and 2025% in REM sleep. Stage 1 lasts 1-7 min (2-5 % of total sleep). Stage 2 lasts approximately 10-25 min constituting 45-55% of the total sleep. In this stage, an individual requires more intense stimuli than in stage 1 to awaken. Stage 3 lasts only a few minutes (3 to 8 % of sleep). Stage 4 of NREM lasts 20-40 min in the first cycle and constitutes 10-15% of sleep. Stages 3 and 4 are classified as the deepest stages of sleep (3,4). REM sleep lasts only 1-5 min during the initial cycle, but is progressively prolonged as sleep progresses. Here, the brain appears to be as active as during wake periods (1); dreaming is associated with this state of sleep. Also, in REM sleep there is a loss of muscle tone and reflexes which is important to prevent the individuals from acting out their dreams while sleeping. REM sleep is important for memory consolidation (3). New approaches towards treatment of insomnia

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تاریخ انتشار 2013